There is yet no solid evidence it provides any benefit against the sarsncov2 virus that causes the deadly respiratory pandemic, but studies are ongoing. Pdf benefit from beta interferon in the treatment of. Pdf longterm impact of interferon beta1b in patients with cis. A nonglycosylated form of interferon beta1 that has a serine at position 17. It is used in the treatment of both relapsingremitting multiple sclerosis and chronic progressive multiple sclerosis. The 2year interferon beta1b ifnb study was the pivotal phase 3 trial of ifn beta1b in patients with rrms and compared the efficacy, safety and tolerability of ifn beta1b and placebo.
Interferon beta1a multiple sclerosis discovery forum. The first study, completed in 1991, involved 372 people with relapsing ms. Clinical trials found that betaferon interferon beta 1b has a significant beneficial effect in people. Interferon beta ifn beta is a cytokine that is produced by fibroblasts and pathogenexposed dendritic cells, macrophages, and endothelial cells. Treatment of secondaryprogressive ms available dosage from the hospital. Two were trials of interferon beta 1a ifnb1a and two of interferon beta 1b. The ifn beta gene was cloned from human fibroblasts and altered to substitute serine for the cysteine residue found at position 17. Many clinical trials evaluated the safety and efficacy of. The use of interferon beta1b for multiple sclerosis ms is based on the assumption that ms is an immunologically mediated illness. Multiple sclerosis ms is characterized by autoimmune inflammation and subsequent neurodegeneration.
How to use interferon beta1b solution, reconstituted recon soln read the medication guide and instructions for use provided by your pharmacist before you start using this medication and each. Betaseron interferon beta1b is a purified, sterile, lyophilized protein product produced by recombinant dna techniques. Difference between interferon beta1a and 1b compare the. Betaseron interferon beta1b is a prescription medicine used to treat relapsing forms of multiple sclerosis ms, to include clinically isolated syndrome, relapsingremitting disease, and active secondary progressive disease, in adults.
Rebif interferon beta1a dose, indications, adverse. Glatiramer and interferon beta 1b are potential alternatives to consider for the treatment of multiple sclerosis. Interferon beta1a, avonex, biogen, inc package insert. Interferon beta 1b was the first diseasemodifying agent to be approved in the united states. In the treatment of multiple sclerosis which is a demyelinating disease, interferon beta 1a and interferon beta. Coli is a single, nonglycosylated mutein variant form of human ifn beta1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510. Pdf current and future role of interferon beta in the therapy of. Avonex interferon beta 1a injection treats multiple sclerosis ms in adults.
Treatment of relapsing forms of multiple sclerosis ms. Betaseron interferon beta 1b is an antiinflammatory therapy for multiple sclerosis currently produced by bayer healthcare. Interferon beta1b has 165 amino acids and an approximate molecular weight of 18,500 daltons. Costeffectiveness of teriflunomide compared to interferon beta1b. Interferon beta and glatiramer acetate therapy ncbi nih. Betaseron, extavia interferon beta 1b dosing, indications. Interferon beta 1a is under investigation as a potential treatment for the covid19 coronavirus disease as of april, 2020. Some claims have been made that interferons produce. Betaseron is the first fdaapproved medicine to reduce disease activity in patients. It signals through the heterodimeric ifnalphabeta receptor. There were 25 msrelated hospitalizations among those taking. The 5year data suggest a 33% reduction in relapse frequency and new or enlarging brain lesions on mri in patients treated with highdose ifnb1b 250 mcg compared to placebo.
The ifnbeta gene was cloned from human fibroblasts and altered to substitute serine for the cysteine residue found at position 17. Interferon beta 1b jordan university of science and. It signals through the heterodimeric ifnalpha beta receptor. Read this medication guide before you start using avonex, and each time you get a refill. Oct 03, 2018 interferon beta 1b can harm your liver. Interferon beta 1b betaseron was approved by the fda in 1993 on the basis of four clinical trials. You should not use interferon beta 1b if you are allergic to interferon beta, albumin, or mannitol. Interferon beta2 definition of interferon beta2 by. The use of interferon beta 1b for multiple sclerosis ms is based on the assumption that ms is an immunologically mediated illness. Moreover, lopinavirritonavir or interferon beta1b has been shown to reduce. Both natural and recombinant dna interferon beta1b possess antiviral, antiproliferative, antitumor, and immunomodulatory activity. Betaferon interferon beta 1b ema54762019 pagina 23. For those recruited and treated between days 7 and 14, interferon beta 1b injection was omitted to avoid its proinflammatory effects. Previous articleprevention and control of noncommunicable diseases in the covid19 response.
Triple combination of interferon beta1b, lopinavirritonavir, and. Aug 29, 2012 multiple sclerosis ms is characterized by autoimmune inflammation and subsequent neurodegeneration. Injectable interferon beta1b for the treatment of relapsing. Interferon beta 1b is a cytokine in the interferon family used to treat the relapsingremitting and secondaryprogressive forms of multiple sclerosis ms. It is not an interferon, but may be grouped with interferon betas avonex and betaseron. Triple combination of interferon beta1b, lopinavir. This division is based on the type of cell that produces the interferon and. Interferon beta 1a avonex like interferon beta 1b this drug is a cytokine that modulates immune responsiveness. Researchers are still investigating exactly how this process works. Dose and frequency of administration of interferonbeta.
Pdf to examine the longterm impact of early treatment initiation of interferon beta1b ifnb1b, betaferonbetaseron in patients with a first event. Betaseron interferon beta 1b for multiple sclerosis. Coli is a single, nonglycosylated mutein variant form of human ifn beta 1b polypeptide chain containing 165 amino acids and having a molecular mass of 18510. Rebif interferonbeta1a is indicated for the treatment of patients with relapsing forms of multiple sclerosis to decrease the frequency of clinical exacerbations.
Interferon beta 1b is manufactured by bacterial fermentation of a strain of escherichia coli that bears a genetically engineered plasmid containing the gene for human interferon. Randall2 1 department of biochemistry and immunology, st georges hospital medical school, university of london, london sw17 0re, uk 2 biomolecular sciences building, north haugh, university of st andrews, fife. Teriflunomide dominated interferon beta1b and was associated with lower. Betaseron interferon beta1b prescription medication. The active ingredient in betaseron is interferon beta1b. Meeting an unmet medical need in the treatment 777. Relapsing and relapsingremitting multiple sclerosis. Clinical practice of analysis of antidrug antibodies against interferon. Interferon beta1b is manufactured by bacterial fermentation of a strain of escherichia coli that bears a genetically engineered. Triple combination of interferon beta1b, lopinavir ritonavir, and ribavirin in the treatment of patients admitted to hospital with covid19. Beta interferons have been shown to slow down activity and disease progression in ms.
You should not use interferon beta1b if you are allergic to interferon beta, albumin, or mannitol. Mar 16, 2010 durelli l, verdun e, barbero p, et al. Apr 09, 2020 avonex interferon beta 1a is a 166 amino acid glycoprotein used to treat relapsing multiple sclerosis ms. Current perspectives on interferon beta1b for the treatment.
Longterm interferon beta1b treatment prevents ms relapses, but a recent study found that interferon beta1b had a negative impact on patients mental health composite score and in most qualityoflife subscales over 2 years. However, combining ribavirin with interferons alfa2a, alfa2b, and beta1a did. It is thought to act by reducing inflammation and the immune response that attacks the bodys myelin. Interferonbeta1a avonex like interferonbeta1b this drug is a cytokine that modulates immune responsiveness. Avonex interferon beta1a is a 166 amino acid glycoprotein with a predicted molecular weight of approximately 22,500 daltons. Interferonbeta1a is given by weekly intramuscular injections. Some claims have been made that interferons produce about an 1838% reduction in the rate of ms relapses. Info adjuvants, immunologic info immunologic factors. Key difference interferon beta 1a vs 1b in the context of modern pharmaceuticals, various types of drugs are synthesized using different technologies in order to develop effective therapeutics against different disease conditions.
Interferon beta is associated with the formation of neutralizing antibodies. Interferon beta1a is designed to be identical to interferon beta that is naturally produced by various cells in the body. These interferons have been classified into two types. Interferonbeta ifnbeta is a cytokine that is produced by fibroblasts and pathogenexposed dendritic cells, macrophages, and endothelial cells. Extavia interferon beta 1b for multiple sclerosis mymsteam. The fda approval of interferon beta1b in 1993 marked a new era in ms care fig.
Independent comparison of interferon incomin trial study group everyotherday interferon beta1b versus onceweekly interferon beta1a for multiple sclerosis. The efficacy of interferonbeta1a in patients with rrms was demonstrated in a randomized, double blind study comparing interferonbeta1a to placebo jacobs et al. Pdf interferon beta was the first specific diseasemodifying therapy licensed for multiple sclerosis ms and in its. Interferon beta1a is under investigation as a potential treatment for the covid19 coronavirus disease as of april, 2020.
Longterm interferon beta 1b treatment prevents ms relapses, but a recent study found that interferon beta 1b had a negative impact on patients mental health composite score and in most qualityoflife subscales over 2 years. Sep 03, 2014 the 2year interferon beta 1b ifnb study was the pivotal phase 3 trial of ifn beta 1b in patients with rrms and compared the efficacy, safety and tolerability of ifn beta 1b and placebo. Combining therapies with interferon beta for relapsing and early. Limited published literature has described the presence of interferon beta1a products in human milk at low levels. However, the standard of care based is to have a mother start diseasemodifying therapy of any type only after complete weaning of their infant. In addition to laboratory tests normally required for monitoring patients with multiple sclerosis, complete blood and differential white blood cell counts, platelet counts and blood chemistries, including liver function tests, are recommended at regular intervals one, three, and six months following introduction of interferon 1b therapy, and. Apr 09, 2020 betaseron interferon beta 1b is a purified, sterile, lyophilized protein product produced by recombinant dna techniques. The specific activity of betaseron is approximately 32 million international units iumg interferon beta lb. The 5year data suggest a 33% reduction in relapse frequency and new or enlarging brain lesions on mri in patients treated with highdose ifnb 1b 250 mcg compared to placebo. Ifn b 1b protein human recombinant ifnbeta 1b prospec. This information does not take the place of talking with your healthcare provider about your medical condition or your treatment. It is produced by mammalian cells, while interferon beta1b is produced in modified e.
Closely related is interferon beta 1a, also indicated for ms, with a very similar drug profile. Keywords fingolimodinterferonbeta 1b cognitive impairmentbriefrepeatablebatterytestbrainatrophy. Objective to evaluate the efficacy, safety, and tolerability of combination therapy with intramuscular interferon beta1a and oral doxycycline, a potent inhibitor of matrix metalloproteinases, in patients with relapsingremitting multiple sclerosis rrms having breakthrough disease activity design openlabel, 7month trial setting louisiana state university health sciences center, shreveport. Summary interferon beta1a vs 1b interferon beta1a and interferon beta1b are two types of therapeutics which are used during the treatment of multiple. Rebif interferon beta1a dose, indications, adverse effects. Interferon beta1a rebif is a protein produced by recombinant dna technology using genetically engineered chinese hamster ovary cells into which the human interferon beta genes have been introduced. Interferon beta 1b definition of interferon beta 1b by. It is a formulation of interferon beta 1b indicated for patients with.
Combination therapy with interferon beta1a and doxycycline. A nonglycosylated form of interferon beta 1 that has a serine at position 17. Glatiramer and interferon beta1b are potential alternatives to consider for the treatment of multiple sclerosis. Interferon beta1b article about interferon beta1b by the. It is produced by recombinant dna technology using genetically engineered chinese hamster ovary cells into which the human interferon beta gene has been introduced. Interferon beta 1a for secondary progressive multiple sclerosis. However, to date, there has been no formal demonstration of a specific. Interferon beta1b was the first diseasemodifying agent to be approved in the united states. Avonex, rebif interferon beta 1a dosing, indications.
This leaflet does not take the place of talking to your healthcare provider. Interferon beta 1a is given by weekly intramuscular injections. Interferon beta 1b has 165 amino acids and an approximate molecular weight of 18,500 daltons. Interferon beta1a also interferon beta 1alpha is a cytokine in the interferon family used to treat multiple sclerosis ms. Interferon beta1b article about interferon beta1b by. In vitro study of the effects of combining ifn in this case ifnb1b and ga suggested an additive effect of the combination. Avonex will not cure ms, it will only decrease the frequency of relapse symptoms.
The efficacy of interferon beta 1a in patients with rrms was demonstrated in a randomized, double blind study comparing interferon beta 1a to placebo jacobs et al. It does not include the carbohydrate side chains found in the natural material. It is believed that early in the disease course, proinflammatory t cells that are activated in the periphery by antigen presentation cross the bloodbrain barrier bbb into the cns directed by various chemotaxic agents. Read the medication guide and instructions for use provided by your pharmacist before you start using interferon beta1a and each time you get a refill. Anonymized data from the different cohorts was merged and.
Interferon beta1b receptor binding induces the expression of proteins that are responsible for the pleiotropic bioactivities of interferon beta1b. Benefit from beta interferon in the treatment of multiple sclerosis combinant forms of beta interferon and costeffect anal yses are needed 15. Interferon beta 1b an overview sciencedirect topics. Interferon beta1b is a cytokine in the interferon family used to treat the relapsingremitting and secondaryprogressive forms of multiple sclerosis ms. Interferon beta 1a rebif treats relapsing multiple sclerosis in adults. Interferon beta1b betaseron, extavia interferon beta1b betaseron, extavia is a medication administered by subcutaneous sc injection, every other day, for the treatment of relapsing forms of ms and people with secondaryprogressive ms who continue to experience relapses or acute attacks. However, to date, there has been no formal demonstration of a. Recombinant human ifnbeta 1a mammalian protein 114151. The exact mechanism of action of copaxone in patients with ms is unknown. Men and women age range, 1855 years with rrms who had received interferon beta1a intramuscularly continuously for at least 6 months and were experiencing breakthrough disease activity annualized relapse rate. Interferon beta 1ainduced severe autoimmune hepatitis.
Call your doctor at once if you have nausea, vomiting, tiredness, itching, dark urine, or jaundice yellowing of your skin or eyes. They do this by helping regulate the immune system, reducing attacks on myelin or nerves. The specific activity of betaseron is approximately 32 million international units iumg interferon betalb. Both drugs dont act as a cure for the disease but effectively reduce the progression of the disease. Both natural and recombinant dna interferon beta 1b possess antiviral, antiproliferative, antitumor, and immunomodulatory activity.
95 1349 480 458 1021 737 1153 52 368 1413 1285 148 464 1322 1019 1410 287 1455 613 423 113 621 1378 701 583 200 61 378 345 1253 1148 564 1202 425 142 489 151 97 993 717 1002 1298 856 1301 567 886